Ontology highlight
ABSTRACT:
SUBMITTER: Adlung L
PROVIDER: S-EPMC5293153 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Adlung Lorenz L Kar Sandip S Wagner Marie-Christine MC She Bin B Chakraborty Sajib S Bao Jie J Lattermann Susen S Boerries Melanie M Busch Hauke H Wuchter Patrick P Ho Anthony D AD Timmer Jens J Schilling Marcel M Höfer Thomas T Klingmüller Ursula U
Molecular systems biology 20170124 1
Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell cycle progression, is poorly understood. Here, we study different hematopoietic cell types, in which AKT and ERK signaling is triggered by erythropoietin (Epo). Although these cell types share the molecular network topology for pro-proliferative Epo signaling, they exhibit distinct proliferative responses. Iteratin ...[more]