Ontology highlight
ABSTRACT:
SUBMITTER: Tabata T
PROVIDER: S-EPMC529326 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Tabata Toshihide T Araishi Kenji K Hashimoto Kouichi K Hashimotodani Yuki Y van der Putten Herman H Bettler Bernhard B Kano Masanobu M
Proceedings of the National Academy of Sciences of the United States of America 20041118 48
Type B gamma-aminobutyric acid receptor (GABABR) is a G protein-coupled receptor that regulates neurotransmitter release and neuronal excitability throughout the brain. In various neurons, GABABRs are concentrated at excitatory synapses. Although these receptors are assumed to respond to GABA spillover from neighboring inhibitory synapses, their function is not fully understood. Here we show a previously undescribed function of GABABR exerted independent of GABA. In cerebellar Purkinje cells, in ...[more]