Ontology highlight
ABSTRACT:
SUBMITTER: Lin S
PROVIDER: S-EPMC5295237 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Marine drugs 20170118 1
Ieodomycin B, which shows in vitro antimicrobial activity, was isolated from a marine <i>Bacillus</i> species. A novel asymmetric total synthetic approach to ieodomycin B using commercially available geraniol was achieved. The approach involves the generation of 1,3-<i>trans</i>-dihydroxyl at C-3 and C-5 positions via a Crimmins-modified Evans aldol reaction and a chelation-controlled Mukaiyama aldol reaction of a <i>p</i>-methoxybenzyl-protected aldehyde, as well as the generation of a lactone ...[more]