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Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants.


ABSTRACT: Objective?To determine whether reduced growth velocity (GV) in extremely low birth weight infants is preceded by elevated inflammatory cytokines. Study Design?GV was determined at 36 weeks' postmenstrual age (PMA) in 768 infants 401 to 1,000?g birth weight (BW). Association between blood cytokines measured through day of life 21 and GV was explored using linear regression models that adjusted for late-onset sepsis (LOS), BW, small for gestational age (SGA), gender, race, energy intake, and center. Results?Serum interleukin-6 (IL-6) was increased at days 14 and 21 in LOS infants. LOS was associated with reduced energy intake and GV for weight (weight-GV) at 36 weeks' PMA. Linear regression analysis controlling for LOS and energy intake showed significant relationships between increased IL-6 at days 14 and 21 with reduced weight-GV at 36 weeks' PMA (p?

SUBMITTER: Denson LA 

PROVIDER: S-EPMC5296404 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Early Elevation in Interleukin-6 is Associated with Reduced Growth in Extremely Low Birth Weight Infants.

Denson Lee A LA   McDonald Scott A SA   Das Abhik A   Schendel Diana E DE   Skogstrand Kristin K   Hougaard David M DM   Shankaran Seetha S   Higgins Rosemary D RD   Carlo Waldemar A WA   Ehrenkranz Richard A RA  

American journal of perinatology 20160725 3


<b>Objective</b> To determine whether reduced growth velocity (GV) in extremely low birth weight infants is preceded by elevated inflammatory cytokines. <b>Study Design</b> GV was determined at 36 weeks' postmenstrual age (PMA) in 768 infants 401 to 1,000 g birth weight (BW). Association between blood cytokines measured through day of life 21 and GV was explored using linear regression models that adjusted for late-onset sepsis (LOS), BW, small for gestational age (SGA), gender, race, energy int  ...[more]

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