Ontology highlight
ABSTRACT:
SUBMITTER: Tsutsui-Kimura I
PROVIDER: S-EPMC5296642 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Tsutsui-Kimura Iku I Takiue Hiroyuki H Yoshida Keitaro K Xu Ming M Yano Ryutaro R Ohta Hiroyuki H Nishida Hiroshi H Bouchekioua Youcef Y Okano Hideyuki H Uchigashima Motokazu M Watanabe Masahiko M Takata Norio N Drew Michael R MR Sano Hiromi H Mimura Masaru M Tanaka Kenji F KF
Nature communications 20170201
Impaired motivation is present in a variety of neurological disorders, suggesting that decreased motivation is caused by broad dysfunction of the nervous system across a variety of circuits. Based on evidence that impaired motivation is a major symptom in the early stages of Huntington's disease, when dopamine receptor type 2-expressing striatal medium spiny neurons (D2-MSNs) are particularly affected, we hypothesize that degeneration of these neurons would be a key node regulating motivational ...[more]