Ontology highlight
ABSTRACT:
SUBMITTER: von Massenhausen A
PROVIDER: S-EPMC5297642 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
von Mässenhausen Anne A Brägelmann Johannes J Billig Hannah H Thewes Britta B Queisser Angela A Vogel Wenzel W Kristiansen Glen G Schröck Andreas A Bootz Friedrich F Brossart Peter P Kirfel Jutta J Perner Sven S
International journal of molecular sciences 20161222 1
Head and neck squamous cell carcinoma (HNSCC) remains a clinical challenge and identification of novel therapeutic targets is necessary. The receptor tyrosine kinase AXL has been implicated in several tumor entities and a selective AXL small molecule inhibitor (BGB324) is currently being tested in clinical trials for patients suffering from non-small cell lung cancer or acute myeloid leukemia. Our study investigates AXL expression during HNSCC progression and its use as a potential therapeutic t ...[more]