Ontology highlight
ABSTRACT:
SUBMITTER: Sylwestrak EL
PROVIDER: S-EPMC5297939 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Sylwestrak Emily L EL Ghosh Anirvan A
Science (New York, N.Y.) 20121004 6106
Although synaptic transmission may be unidirectional, the establishment of synaptic connections with specific properties can involve bidirectional signaling. Pyramidal neurons in the hippocampus form functionally distinct synapses onto two types of interneurons. Excitatory synapses onto oriens-lacunosum moleculare (O-LM) interneurons are facilitating and have a low release probability, whereas synapses onto parvalbumin interneurons are depressing and have a high release probability. Here, we sho ...[more]