Ontology highlight
ABSTRACT:
SUBMITTER: Scullin CS
PROVIDER: S-EPMC4562807 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Scullin Chessa S CS Schiess Adrian R B AR Donald Partridge L L
Brain research 20150620
In order to explore short-term facilitation of the Schaffer collateral to CA1 synapse in mouse hippocampal brain slices, we measured the time course of the decay of the peak amplitude of successive EPSCs during progressive MK-801-dependent block (PMDB) of NMDAR responses to paired (R1 and R2) stimuli. We made the unexpected observation that the R2 response exhibited a slower PMDB decay constant than that of the R1 response. This indicated that the facilitated R2 response engages release sites wi ...[more]