Ontology highlight
ABSTRACT:
SUBMITTER: Guan H
PROVIDER: S-EPMC5299019 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Guan Huai H Song Shuaibao S Robinson Howard H Liang Jing J Ding Haizhen H Li Jianyong J Han Qian Q
Frontiers in molecular biosciences 20170209
Tyrosine decarboxylase (TyDC), a type II pyridoxal 5'-phosphate decarboxylase, catalyzes the decarboxylation of tyrosine. Due to a generally high sequence identity to other aromatic amino acid decarboxylases (AAADs), primary sequence information is not enough to understand substrate specificities with structural information. In this study, we selected a typical TyDC from <i>Papaver somniferum</i> as a model to study the structural basis of AAAD substrate specificities. Analysis of the native <i> ...[more]