Ontology highlight
ABSTRACT:
SUBMITTER: Song H
PROVIDER: S-EPMC5299047 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20170119 2
Double-stranded RNA (dsRNA)-specific RNase III proteins are required for RNA maturation and gene regulation. The mechanism of prokaryotic RNase IIIs has been well characterized, but how eukaryotic RNase IIIs (exemplified by Rnt1p, Drosha, and Dicer) work is less clear. Recently, we reported the crystal structure of Rnt1p in complex with RNA, revealing a double-ruler mechanism for substrate selection. Here, we present more structures of Rnt1p, either RNA free or RNA bound, featuring two major con ...[more]