Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204.
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ABSTRACT:
SUBMITTER: Veno MT
PROVIDER: S-EPMC5299138 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204.
Venø Morten T MT Venø Susanne T ST Rehberg Kati K van Asperen Jessy V JV Clausen Bettina H BH Holm Ida E IE Pasterkamp R Jeroen RJ Finsen Bente B Kjems Jørgen J
Frontiers in molecular neuroscience 20170209
The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. <i>In vivo</i> modulation of miRN ...[more]
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