Unknown

Dataset Information

0

Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204.


ABSTRACT: The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. In vivo modulation of miRNA expression in mouse embryos confirmed that miR-34c and miR-204 can control neuronal migration and cortical morphogenesis, presumably by posttranscriptional regulation of DCX.

SUBMITTER: Veno MT 

PROVIDER: S-EPMC5299138 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

altmetric image

Publications

Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204.

Venø Morten T MT   Venø Susanne T ST   Rehberg Kati K   van Asperen Jessy V JV   Clausen Bettina H BH   Holm Ida E IE   Pasterkamp R Jeroen RJ   Finsen Bente B   Kjems Jørgen J  

Frontiers in molecular neuroscience 20170209


The porcine brain closely resembles the human brain in aspects such as development and morphology. Temporal miRNA profiling in the developing embryonic porcine cortex revealed a distinct set of miRNAs, including miR-34c and miR-204, which exhibited a highly specific expression profile across the time of cortical folding. These miRNAs were found to target Doublecortin (DCX), known to be involved in neuron migration during cortical folding of gyrencephalic brains. <i>In vivo</i> modulation of miRN  ...[more]

Similar Datasets

| S-EPMC5555168 | biostudies-literature
| S-EPMC3373245 | biostudies-literature
| S-EPMC5599891 | biostudies-literature
| S-EPMC5571228 | biostudies-literature
| S-EPMC10131327 | biostudies-literature
| S-EPMC7010400 | biostudies-literature
| S-EPMC3535469 | biostudies-literature
2013-12-01 | GSE41322 | GEO
| S-EPMC7332994 | biostudies-literature
| S-EPMC2932609 | biostudies-literature