Ontology highlight
ABSTRACT:
SUBMITTER: Matern M
PROVIDER: S-EPMC5299610 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Matern Maggie M Vijayakumar Sarath S Margulies Zachary Z Milon Beatrice B Song Yang Y Elkon Ran R Zhang Xiaoyu X Jones Sherri M SM Hertzano Ronna R
Scientific reports 20170209
Studies of developmental and functional biology largely rely on conditional expression of genes in a cell type-specific manner. Therefore, the importance of specificity and lack of inherent phenotypes for Cre-driver animals cannot be overemphasized. The Gfi1<sup>Cre</sup> mouse is commonly used for conditional hair cell-specific gene deletion/reporter gene activation in the inner ear. Here, using immunofluorescence and flow cytometry, we show that the Gfi1<sup>Cre</sup> mice produce a pattern of ...[more]