Ontology highlight
ABSTRACT:
SUBMITTER: Pinto M
PROVIDER: S-EPMC5299712 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Cell death and differentiation 20161202 2
We observed that the transient induction of mtDNA double strand breaks (DSBs) in cultured cells led to activation of cell cycle arrest proteins (p21/p53 pathway) and decreased cell growth, mediated through reactive oxygen species (ROS). To investigate this process in vivo we developed a mouse model where we could transiently induce mtDNA DSBs ubiquitously. This transient mtDNA damage in mice caused an accelerated aging phenotype, preferentially affecting proliferating tissues. One of the earlies ...[more]