Ontology highlight
ABSTRACT:
SUBMITTER: Halberg N
PROVIDER: S-EPMC5300038 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Cancer cell 20160301 3
Enhanced secretion of tumorigenic effector proteins is a feature of malignant cells. The molecular mechanisms underlying this feature are poorly defined. We identify PITPNC1 as a gene amplified in a large fraction of human breast cancer and overexpressed in metastatic breast, melanoma, and colon cancers. Biochemical, molecular, and cell-biological studies reveal that PITPNC1 promotes malignant secretion by binding Golgi-resident PI4P and localizing RAB1B to the Golgi. RAB1B localization to the G ...[more]