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Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.

ABSTRACT: We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.

SUBMITTER: Bartha I

PROVIDER: S-EPMC5300119 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.

Bartha István I McLaren Paul J PJ Brumme Chanson C Harrigan Richard R Telenti Amalio A Fellay Jacques J

PLoS computational biology 20170209 2

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation. ...[more]

PMID: 28182649

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