Ontology highlight
ABSTRACT:
SUBMITTER: Bantele SC
PROVIDER: S-EPMC5300703 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Bantele Susanne Cs SC Ferreira Pedro P Gritenaite Dalia D Boos Dominik D Pfander Boris B
eLife 20170112
DNA double strand breaks (DSBs) can be repaired by either recombination-based or direct ligation-based mechanisms. Pathway choice is made at the level of DNA end resection, a nucleolytic processing step, which primes DSBs for repair by recombination. Resection is thus under cell cycle control, but additionally regulated by chromatin and nucleosome remodellers. Here, we show that both layers of control converge in the regulation of resection by the evolutionarily conserved Fun30/SMARCAD1 remodell ...[more]