Ontology highlight
ABSTRACT:
SUBMITTER: Ryu KA
PROVIDER: S-EPMC5300779 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
ACS chemical biology 20161025 12
We report immune response modulation with linked Toll-like receptor (TLR) agonists. Conjugating two agonists of synergistic TLRs induce an increase in immune activity compared to equal molarity of soluble agonists. Additionally, varying the distance between the agonists by changing the linker length alters the level of macrophage NF-κB activity as well as primary bone marrow derived dendritic cell IL-6 production. This modulation is effected by the size of the agonists and the pairing of the sti ...[more]