Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Macrophage
SUBMITTER: Nicholas Riley
LAB HEAD: Carolyn Bertozzi
PROVIDER: PXD018774 | Pride | 2021-01-14
REPOSITORIES: Pride
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2019_11_11_LPS_FT_1.raw | Raw | |||
2019_11_11_LPS_FT_2.raw | Raw | |||
2019_11_11_LPS_FT_3.raw | Raw | |||
2019_11_11_LPS_Phos_1.raw | Raw | |||
2019_11_11_LPS_Phos_2.raw | Raw |
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Proceedings of the National Academy of Sciences of the United States of America 20210101 3
Inflammatory pathologies caused by phagocytes lead to numerous debilitating conditions, including chronic pain and blindness due to age-related macular degeneration. Many members of the sialic acid-binding immunoglobulin-like lectin (Siglec) family are immunoinhibitory receptors whose agonism is an attractive approach for antiinflammatory therapy. Here, we show that synthetic lipid-conjugated glycopolypeptides can insert into cell membranes and engage Siglec receptors in <i>cis</i>, leading to i ...[more]