Dataset Information

Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches.

ABSTRACT: Almost every experimental treatment strategy using non-autologous cell, tissue or organ transplantation is tested in small and large animal models before clinical translation. Because these strategies require immunosuppression in most cases, immunosuppressive protocols are a key element in transplantation experiments. However, standard immunosuppressive protocols are often applied without detailed knowledge regarding their efficacy within the particular experimental setting and in the chosen model species. Optimization of such protocols is pertinent to the translation of experimental results to human patients and thus warrants further investigation. This review summarizes current knowledge regarding immunosuppressive drug classes as well as their dosages and application regimens with consideration of species-specific drug metabolization and side effects. It also summarizes contemporary knowledge of novel immunomodulatory strategies, such as the use of mesenchymal stem cells or antibodies. Thus, this review is intended to serve as a state-of-the-art compendium for researchers to refine applied experimental immunosuppression and immunomodulation strategies to enhance the predictive value of preclinical transplantation studies.

SUBMITTER: Diehl R

PROVIDER: S-EPMC5301156 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches.

Diehl Rita R Ferrara Fabienne F Müller Claudia C Dreyer Antje Y AY McLeod Damian D DD Fricke Stephan S Boltze Johannes J

Cellular & molecular immunology 20161010 2

Almost every experimental treatment strategy using non-autologous cell, tissue or organ transplantation is tested in small and large animal models before clinical translation. Because these strategies require immunosuppression in most cases, immunosuppressive protocols are a key element in transplantation experiments. However, standard immunosuppressive protocols are often applied without detailed knowledge regarding their efficacy within the particular experimental setting and in the chosen mod ...[more]

PMID: 27721455

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Dataset Information

Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches.

Publications

Immunosuppression for in vivo research: state-of-the-art protocols and experimental approaches.

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