Ontology highlight
ABSTRACT:
SUBMITTER: Kobayashi N
PROVIDER: S-EPMC5301220 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Kobayashi Norio N Miyauchi Naoko N Tatsuta Nozomi N Kitamura Akane A Okae Hiroaki H Hiura Hitoshi H Sato Akiko A Utsunomiya Takafumi T Yaegashi Nobuo N Nakai Kunihiko K Arima Takahiro T
Scientific reports 20170210
Disturbingly, the number of patients with oligozoospermia (low sperm count) has been gradually increasing in industrialized countries. Epigenetic alterations are believed to be involved in this condition. Recent studies have clarified that intrinsic and extrinsic factors can induce epigenetic transgenerational phenotypes through apparent reprogramming of the male germ line. Here we examined DNA methylation levels of 22 human imprinted loci in a total of 221 purified sperm samples from infertile ...[more]