Ontology highlight
ABSTRACT:
SUBMITTER: Reus LM
PROVIDER: S-EPMC5301496 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Reus L M LM Shen X X Gibson J J Wigmore E E Ligthart L L Adams M J MJ Davies G G Cox S R SR Hagenaars S P SP Bastin M E ME Deary I J IJ Whalley H C HC McIntosh A M AM
Scientific reports 20170210
Major depressive disorder (MDD), schizophrenia (SCZ) and bipolar disorder (BP) are common, disabling and heritable psychiatric diseases with a complex overlapping polygenic architecture. Individuals with these disorders, as well as their unaffected relatives, show widespread structural differences in corticostriatal and limbic networks. Structural variation in many of these brain regions is also heritable and polygenic but whether their genetic architecture overlaps with that of major psychiatri ...[more]