Ontology highlight
ABSTRACT:
SUBMITTER: Grama S
PROVIDER: S-EPMC7481214 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Grama Steluta S Willcocks Isabella I Hubert John J JJ Pardiñas Antonio F AF Legge Sophie E SE Bracher-Smith Matthew M Menzies Georgina E GE Hall Lynsey S LS Pocklington Andrew J AJ Anney Richard J L RJL Bray Nicholas J NJ Escott-Price Valentina V Caseras Xavier X
Translational psychiatry 20200909 1
Research has shown differences in subcortical brain volumes between participants with schizophrenia and healthy controls. However, none of these differences have been found to associate with schizophrenia polygenic risk. Here, in a large sample (n = 14,701) of unaffected participants from the UK Biobank, we test whether schizophrenia polygenic risk scores (PRS) limited to specific gene-sets predict subcortical brain volumes. We compare associations with schizophrenia PRS at the whole genome leve ...[more]