Ontology highlight
ABSTRACT:
SUBMITTER: Guo CJ
PROVIDER: S-EPMC5302092 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Guo Chun-Jun CJ Chang Fang-Yuan FY Wyche Thomas P TP Backus Keriann M KM Acker Timothy M TM Funabashi Masanori M Taketani Mao M Donia Mohamed S MS Nayfach Stephen S Pollard Katherine S KS Craik Charles S CS Cravatt Benjamin F BF Clardy Jon J Voigt Christopher A CA Fischbach Michael A MA
Cell 20170119 3
The gut microbiota modulate host biology in numerous ways, but little is known about the molecular mediators of these interactions. Previously, we found a widely distributed family of nonribosomal peptide synthetase gene clusters in gut bacteria. Here, by expressing a subset of these clusters in Escherichia coli or Bacillus subtilis, we show that they encode pyrazinones and dihydropyrazinones. At least one of the 47 clusters is present in 88% of the National Institutes of Health Human Microbiome ...[more]