Ontology highlight
ABSTRACT:
SUBMITTER: Liu K
PROVIDER: S-EPMC5302953 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Liu Kun K Zhang Yuening Y Zhang Chengdong C Zhang Qinle Q Li Jiatong J Xiao Feifan F Li Yingfang Y Zhang Ruoheng R Dou Dongwei D Liang Jiezhen J Qin Jian J Lin Zhidi Z Zhao Dong D Jiang Min M Liang Zhenxin Z Su Jie J Gupta Vanaparthy Pranay VP He Min M Yang Xiaoli X
Oncotarget 20160801 35
The abnormality of DNA methylation is one of the major epigenetic alterations in the human hepatocellular carcinoma (HCC). We have assessed the global genomic DNA methylation profiles in human HCC patients by using the Infinium Human Methylation27 BeadChip. A CpG loci of S100A8 was found to be significantly hypomethylated in HCC.Pooled meta-analysis of five validation public datasets demonstrated its methylation level was significantly lower for HCC compared to paired adjacent normal tissues. Qu ...[more]