Ontology highlight
ABSTRACT:
SUBMITTER: Cowan AJ
PROVIDER: S-EPMC5303179 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Cowan Andrew J AJ Stevenson Phillip A PA Gooley Ted A TA Frayo Shani L SL Oliveira George R GR Smith Stephen D SD Green Damian J DJ Roden Jennifer E JE Pagel John M JM Wood Brent L BL Press Oliver W OW Gopal Ajay K AK
British journal of haematology 20170105 4
Fenretinide, a synthetic retinoid, induces apoptotic cell death in B-cell non-Hodgkin lymphoma (B-NHL) and acts synergistically with rituximab in preclinical models. We report results from a phase I-II study of fenretinide with rituximab for B-NHLs. Eligible diagnoses included indolent B-NHL or mantle cell lymphoma. The phase I design de-escalated from fenretinide at 900 mg/m<sup>2</sup> PO BID for days 1-5 of a 7-day cycle. The phase II portion added 375 mg/m<sup>2</sup> IV rituximab weekly on ...[more]