Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC5305258 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Lee Jinmin J Sengupta Prabuddha P Brzostowski Joseph J Lippincott-Schwartz Jennifer J Pierce Susan K SK
Molecular biology of the cell 20161214 4
B-cell activation is initiated by the binding of antigen to the B-cell receptor (BCR). Here we used dSTORM superresolution imaging to characterize the nanoscale spatial organization of immunoglobulin M (IgM) and IgG BCRs on the surfaces of resting and antigen--activated human peripheral blood B-cells. We provide insights into both the fundamental process of antigen-driven BCR clustering and differences in the spatial organization of IgM and IgG BCRs that may contribute to the characteristic diff ...[more]