Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.
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ABSTRACT:
SUBMITTER: Mallawaaratchy DM
PROVIDER: S-EPMC5306193 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease.
Mallawaaratchy Duthika M DM Hallal Susannah S Russell Ben B Ly Linda L Ebrahimkhani Saeideh S Wei Heng H Christopherson Richard I RI Buckland Michael E ME Kaufman Kimberley L KL
Journal of neuro-oncology 20161021 2
Extracellular vesicles (EVs) play key roles in glioblastoma (GBM) biology and represent novel sources of biomarkers that are detectable in the peripheral circulation. Despite this notionally non-invasive approach to assess GBM tumours in situ, a comprehensive GBM EV protein signature has not been described. Here, EVs secreted by six GBM cell lines were isolated and analysed by quantitative high-resolution mass spectrometry. Overall, 844 proteins were identified in the GBM EV proteome, of which 1 ...[more]
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