Ontology highlight
ABSTRACT:
SUBMITTER: Meng P
PROVIDER: S-EPMC5308240 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Meng Ping P Huang Honggang H Wang Gan G Yang Shilong S Lu Qiuming Q Liu Jingze J Lai Ren R Rong Mingqiang M
Toxins 20161226 1
Spider venoms are a complex mixture of peptides with a large number of neurotoxins targeting ion channels. Although thousands of peptide toxins have been identified from venoms of numerous species of spiders, many unknown species urgently need to be investigated. In this study, a novel sodium channel inhibitor, µ-TRTX-Hl1a, was identified from the venom of <i>Haplopelma lividum</i>. It contained eight cysteines and formed a conserved cysteine pattern of ICK motif. µ-TRTX-Hl1a inhibited the TTX-r ...[more]