Ontology highlight
ABSTRACT:
SUBMITTER: Woo SM
PROVIDER: S-EPMC5308669 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Woo Seon Min SM Min Kyoung-Jin KJ Seo Bo Ram BR Kwon Taeg Kyu TK
Oncotarget 20160901 38
YM155, a small-molecule survivin inhibitor, has been reported for its anti-cancer activity in various cancer cells. In this study, we investigated the effect of YM155 to enhance TRAIL-mediated apoptosis in human renal carcinoma cells. We found that YM155 alone had no effect on apoptosis, however, combined treatment with YM155 and TRAIL markedly induced apoptosis in human renal carcinoma cells (Caki, ACHN, and A498), breast cancer cells (MDA-MB231), and glioma cells (U251MG), but not normal cells ...[more]