Ontology highlight
ABSTRACT:
SUBMITTER: Krook MA
PROVIDER: S-EPMC5308690 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Krook Melanie A MA Hawkins Allegra G AG Patel Rajiv M RM Lucas David R DR Van Noord Raelene R Chugh Rashmi R Lawlor Elizabeth R ER
Oncotarget 20160901 38
Tumor heterogeneity is a major impediment to cancer cures. Tumor cell heterogeneity can arise by irreversible genetic mutation, as well as by non-mutational mechanisms, which can be reversibly modulated by the tumor microenvironment and the epigenome. We recently reported that the chemokine receptor CXCR4 is induced in Ewing sarcoma cells in response to microenvironmental stress. In the current study, we investigated plasticity of CXCR4 expression in vivo and assessed whether CXCR4 impacts on tu ...[more]