Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC5309293 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Wang Ziqiang Z Fan Ping P Zhao Yiwan Y Zhang Shikuan S Lu Jinhua J Xie Weidong W Jiang Yuyang Y Lei Fan F Xu Naihan N Zhang Yaou Y
Cellular and molecular life sciences : CMLS 20161025 6
Nuclear paraspeckle assembly transcript 1 (NEAT1) is the crucial structural platform of paraspeckles, which is one type of nuclear bodies. As a stress-induced lncRNA, the expression of NEAT1 increases in response to viral infection, but little is known about the role of NEAT1 or paraspeckles in the replication of herpes simplex virus-1 (HSV-1). Here, we demonstrate that HSV-1 infection increases NEAT1 expression and paraspeckle formation in a STAT3-dependent manner. NEAT1 and other paraspeckle p ...[more]