Ontology highlight
ABSTRACT:
SUBMITTER: Qin CX
PROVIDER: S-EPMC5309721 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Qin Cheng Xue CX May Lauren T LT Li Renming R Cao Nga N Rosli Sarah S Deo Minh M Alexander Amy E AE Horlock Duncan D Bourke Jane E JE Yang Yuan H YH Stewart Alastair G AG Kaye David M DM Du Xiao-Jun XJ Sexton Patrick M PM Christopoulos Arthur A Gao Xiao-Ming XM Ritchie Rebecca H RH
Nature communications 20170207
Effective treatment for managing myocardial infarction (MI) remains an urgent, unmet clinical need. Formyl peptide receptors (FPR) regulate inflammation, a major contributing mechanism to cardiac injury following MI. Here we demonstrate that FPR1/FPR2-biased agonism may represent a novel therapeutic strategy for the treatment of MI. The small-molecule FPR1/FPR2 agonist, Compound 17b (Cmpd17b), exhibits a distinct signalling fingerprint to the conventional FPR1/FPR2 agonist, Compound-43 (Cmpd43). ...[more]