Ontology highlight
ABSTRACT:
SUBMITTER: Larsen SE
PROVIDER: S-EPMC5310646 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Larsen Sasha E SE Bilenkin Abegail A Tarasenko Tatiana N TN Arjunaraja Swadhinya S Stinson Jeffrey R JR McGuire Peter J PJ Snow Andrew L AL
Journal of immunology (Baltimore, Md. : 1950) 20161116 1
Restimulation-induced cell death (RICD) regulates immune responses by restraining effector T cell expansion and limiting nonspecific damage to the host. RICD is triggered by re-engagement of the TCR on a cycling effector T cell, resulting in apoptosis. It remains unclear how RICD sensitivity is calibrated in T cells derived from different individuals or subsets. In this study we show that aerobic glycolysis strongly correlates with RICD sensitivity in human CD8<sup>+</sup> effector T cells. Redu ...[more]