Fatty Acid Synthase Contributes to Restimulation-Induced Cell Death of Human CD4 T Cells.

ABSTRACT: Restimulation-induced cell death (RICD) is an apoptotic pathway triggered in activated effector T cells after T cell receptor (TCR) re-engagement. RICD operates at the peak of the immune response to ensure T cell expansion remains in check to maintain immune homeostasis. Understanding the biochemical regulation of RICD sensitivity may provide strategies for tuning the magnitude of an effector T cell response. Metabolic reprogramming in activated T cells is not only critical for T cell differentiation and effector functions, but also influences apoptosis sensitivity. We previously demonstrated that aerobic glycolysis correlates with optimum RICD sensitivity in human effector CD8 T cells. However, metabolic programming in CD4 T cells has not been investigated in this context. We employed a p

SUBMITTER: Voss K 

PROVIDER: S-EPMC6803432 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature