Ontology highlight
ABSTRACT:
SUBMITTER: Reddy DS
PROVIDER: S-EPMC5310676 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Reddy Doodipala Samba DS Estes William A WA
Trends in pharmacological sciences 20160505 7
Neurosteroids are key endogenous molecules in the brain that affect many neural functions. We describe here recent advances in US National Institutes of Health (NIH)-sponsored and other clinical studies of neurosteroids for CNS disorders. The neuronal GABA-A receptor chloride channel is one of the prime molecular targets of neurosteroids. Allopregnanolone-like neurosteroids are potent allosteric agonists as well as direct activators of both synaptic and extrasynaptic GABA-A receptors. Hence, neu ...[more]