Ontology highlight
ABSTRACT:
SUBMITTER: Furlow PW
PROVIDER: S-EPMC5310712 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Furlow Paul W PW Zhang Steven S Soong T David TD Halberg Nils N Goodarzi Hani H Mangrum Creed C Wu Y Gloria YG Elemento Olivier O Tavazoie Sohail F SF
Nature cell biology 20150622 7
During metastatic progression, circulating cancer cells become lodged within the microvasculature of end organs, where most die from mechanical deformation. Although this phenomenon was first described over a half-century ago, the mechanisms enabling certain cells to survive this metastasis-suppressive barrier remain unknown. By applying whole-transcriptome RNA-sequencing technology to isogenic cancer cells of differing metastatic capacities, we identified a mutation encoding a truncated form of ...[more]