Ontology highlight
ABSTRACT:
SUBMITTER: Chekeni FB
PROVIDER: S-EPMC3006164 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Chekeni Faraaz B FB Elliott Michael R MR Sandilos Joanna K JK Walk Scott F SF Kinchen Jason M JM Lazarowski Eduardo R ER Armstrong Allison J AJ Penuela Silvia S Laird Dale W DW Salvesen Guy S GS Isakson Brant E BE Bayliss Douglas A DA Ravichandran Kodi S KS
Nature 20101001 7317
Apoptotic cells release 'find-me' signals at the earliest stages of death to recruit phagocytes. The nucleotides ATP and UTP represent one class of find-me signals, but their mechanism of release is not known. Here, we identify the plasma membrane channel pannexin 1 (PANX1) as a mediator of find-me signal/nucleotide release from apoptotic cells. Pharmacological inhibition and siRNA-mediated knockdown of PANX1 led to decreased nucleotide release and monocyte recruitment by apoptotic cells. Conver ...[more]