Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5311249 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Zhang X X Zhang L L Du Y Y Zheng H H Zhang P P Sun Y Y Wang Y Y Chen J J Ding P P Wang N N Yang C C Huang T T Yao X X Qiao Q Q Gu H H Cai G G Cai S S Zhou X X Hu W W
Oncogene 20160711 6
Epithelial-mesenchymal transition (EMT) is a critical event in metastasis of colorectal cancer (CRC). Rho/ROCKs signaling has a pivotal role in orchestrating actin cytoskeleton, leading to EMT and cancer invasion. However, the underlying mechanisms for ROCKs activation are not fully understood. Here, we identified FOXM1D, a novel isoform of Forkhead box M1 (FOXM1) that has a pivotal role in ROCKs activation by directly interacting with coiled-coil region of ROCK2. FOXM1D overexpression significa ...[more]