Ontology highlight
ABSTRACT:
SUBMITTER: Dong Q
PROVIDER: S-EPMC5311718 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Dong Qian Q Li Jing J Wu Qiong-Feng QF Zhao Ning N Qian Cheng C Ding Dan D Wang Bin-Bin BB Chen Lei L Guo Ke-Fang KF Fu Dehao D Han Bing B Liao Yu-Hua YH Du Yi-Mei YM
Scientific reports 20170216
Transient receptor potential vanilloid 4 (TRPV4) is a Ca<sup>2+</sup>-permeable nonselective cation channel and can be activated during ischemia/reperfusion (I/R). This study tested whether blockade of TRPV4 can alleviate myocardial I/R injury in mice. TRPV4 expression began to increase at 1 h, reached statistically at 4 h, and peaked at 24-72 h. Treatment with the selective TRPV4 antagonist HC-067047 or TRPV4 knockout markedly ameliorated myocardial I/R injury as demonstrated by reduced infarct ...[more]