Ontology highlight
ABSTRACT:
SUBMITTER: Johnson AG
PROVIDER: S-EPMC5311923 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Johnson Alex G AG Grosely Rosslyn R Petrov Alexey N AN Puglisi Joseph D JD
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20170301 1716
Viral internal ribosome entry sites (IRESs) are unique RNA elements, which use stable and dynamic RNA structures to recruit ribosomes and drive protein synthesis. IRESs overcome the high complexity of the canonical eukaryotic translation initiation pathway, often functioning with a limited set of eukaryotic initiation factors. The simplest types of IRESs are typified by the cricket paralysis virus intergenic region (CrPV IGR) and hepatitis C virus (HCV) IRESs, both of which independently form hi ...[more]