Ontology highlight
ABSTRACT:
SUBMITTER: Grinshtein N
PROVIDER: S-EPMC5312317 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Grinshtein Natalie N Rioseco Constanza C CC Marcellus Richard R Uehling David D Aman Ahmed A Lun Xueqing X Muto Osamu O Podmore Lauren L Lever Jake J Shen Yaoqing Y Blough Michael D MD Cairncross Greg J GJ Robbins Stephen M SM Jones Steven J SJ Marra Marco A MA Al-Awar Rima R Senger Donna L DL Kaplan David R DR
Oncotarget 20160901 37
Glioblastoma (GBM) is the most lethal and aggressive adult brain tumor, requiring the development of efficacious therapeutics. Towards this goal, we screened five genetically distinct patient-derived brain-tumor initiating cell lines (BTIC) with a unique collection of small molecule epigenetic modulators from the Structural Genomics Consortium (SGC). We identified multiple hits that inhibited the growth of BTICs in vitro, and further evaluated the therapeutic potential of EZH2 and HDAC inhibitor ...[more]