Ontology highlight
ABSTRACT:
SUBMITTER: Du W
PROVIDER: S-EPMC5312365 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Du Wei W Amarachintha Surya S Erden Ozlem O Wilson Andrew A Pang Qishen Q
Oncotarget 20160901 37
The Fanconi anemia (FA) pathway is involved in DNA damage and other cellular stress responses. We have investigated the role of the FA pathway in oncogenic stress response by employing an in vivo stress-response model expressing the Gadd45β-luciferase transgene. Using two inducible models of oncogenic activation (LSL-K-rasG12D and MycER), we show that hematopoietic stem and progenitor cells (HSPCs) from mice deficient for the FA core complex components Fanca or Fancc exhibit aberrant short-lived ...[more]