Ontology highlight
ABSTRACT:
SUBMITTER: Spitzer MH
PROVIDER: S-EPMC5312823 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Spitzer Matthew H MH Carmi Yaron Y Reticker-Flynn Nathan E NE Kwek Serena S SS Madhireddy Deepthi D Martins Maria M MM Gherardini Pier Federico PF Prestwood Tyler R TR Chabon Jonathan J Bendall Sean C SC Fong Lawrence L Nolan Garry P GP Engleman Edgar G EG
Cell 20170119 3
Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass cytometry. We analyzed immune responses in several tissues after immunotherapy by developing intuitive models for visualizing single-cell data with statistical inference. Immune ac ...[more]