Ontology highlight
ABSTRACT:
SUBMITTER: Coleman MF
PROVIDER: S-EPMC7225951 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Coleman Michael F MF Cozzo Alyssa J AJ Pfeil Alexander J AJ Etigunta Suhas K SK Hursting Stephen D SD
Cancers 20200401 4
Immune checkpoint inhibitor (ICI) therapy has shown extraordinary promise at treating cancers otherwise resistant to treatment. However, for ICI therapy to be effective, it must overcome the metabolic limitations of the tumor microenvironment. Tumor metabolism has long been understood to be highly dysregulated, with potent immunosuppressive effects. Moreover, T cell activation and longevity within the tumor microenvironment are intimately tied to T cell metabolism and are required for the long-t ...[more]