Ontology highlight
ABSTRACT:
SUBMITTER: Katlinski KV
PROVIDER: S-EPMC5313042 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Katlinski Kanstantsin V KV Gui Jun J Katlinskaya Yuliya V YV Ortiz Angelíca A Chakraborty Riddhita R Bhattacharya Sabyasachi S Carbone Christopher J CJ Beiting Daniel P DP Girondo Melanie A MA Peck Amy R AR Puré Ellen E Chatterji Priya P Rustgi Anil K AK Diehl J Alan JA Koumenis Constantinos C Rui Hallgeir H Fuchs Serge Y SY
Cancer cell 20170201 2
Refractoriness of solid tumors, including colorectal cancers (CRCs), to immunotherapies is attributed to the immunosuppressive tumor microenvironment that protects malignant cells from cytotoxic T lymphocytes (CTLs). We found that downregulation of the type I interferon receptor chain IFNAR1 occurs in human CRC and mouse models of CRC. Downregulation of IFNAR1 in tumor stroma stimulated CRC development and growth, played a key role in formation of the immune-privileged niche, and predicted poor ...[more]