Ontology highlight
ABSTRACT:
SUBMITTER: Aiello I
PROVIDER: S-EPMC7556830 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Aiello I I Mul Fedele M L ML Román F F Marpegan L L Caldart C C Chiesa J J JJ Golombek D A DA Finkielstein C V CV Paladino N N
Science advances 20201014 42
Circadian disruption negatively affects physiology, posing a global health threat that manifests in proliferative, metabolic, and immune diseases, among others. Because outputs of the circadian clock regulate daily fluctuations in the immune response, we determined whether circadian disruption results in tumor-associated immune cell remodeling, facilitating tumor growth. Our findings show that tumor growth rate increased and latency decreased under circadian disruption conditions compared to nor ...[more]