Ontology highlight
ABSTRACT:
SUBMITTER: Webb TR
PROVIDER: S-EPMC5314135 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Webb Thomas R TR Erdmann Jeanette J Stirrups Kathleen E KE Stitziel Nathan O NO Masca Nicholas G D NG Jansen Henning H Kanoni Stavroula S Nelson Christopher P CP Ferrario Paola G PG König Inke R IR Eicher John D JD Johnson Andrew D AD Hamby Stephen E SE Betsholtz Christer C Ruusalepp Arno A Franzén Oscar O Schadt Eric E EE Björkegren Johan L M JL Weeke Peter E PE Auer Paul L PL Schick Ursula M UM Lu Yingchang Y Zhang He H Dube Marie-Pierre MP Goel Anuj A Farrall Martin M Peloso Gina M GM Won Hong-Hee HH Do Ron R van Iperen Erik E Kruppa Jochen J Mahajan Anubha A Scott Robert A RA Willenborg Christina C Braund Peter S PS van Capelleveen Julian C JC Doney Alex S F AS Donnelly Louise A LA Asselta Rosanna R Merlini Pier A PA Duga Stefano S Marziliano Nicola N Denny Josh C JC Shaffer Christian C El-Mokhtari Nour Eddine NE Franke Andre A Heilmann Stefanie S Hengstenberg Christian C Hoffmann Per P Holmen Oddgeir L OL Hveem Kristian K Jansson Jan-Håkan JH Jöckel Karl-Heinz KH Kessler Thorsten T Kriebel Jennifer J Laugwitz Karl L KL Marouli Eirini E Martinelli Nicola N McCarthy Mark I MI Van Zuydam Natalie R NR Meisinger Christa C Esko Tõnu T Mihailov Evelin E Escher Stefan A SA Alver Maris M Moebus Susanne S Morris Andrew D AD Virtamo Jarma J Nikpay Majid M Olivieri Oliviero O Provost Sylvie S AlQarawi Alaa A Robertson Neil R NR Akinsansya Karen O KO Reilly Dermot F DF Vogt Thomas F TF Yin Wu W Asselbergs Folkert W FW Kooperberg Charles C Jackson Rebecca D RD Stahl Eli E Müller-Nurasyid Martina M Strauch Konstantin K Varga Tibor V TV Waldenberger Melanie M Zeng Lingyao L Chowdhury Rajiv R Salomaa Veikko V Ford Ian I Jukema J Wouter JW Amouyel Philippe P Kontto Jukka J Nordestgaard Børge G BG Ferrières Jean J Saleheen Danish D Sattar Naveed N Surendran Praveen P Wagner Aline A Young Robin R Howson Joanna M M JM Butterworth Adam S AS Danesh John J Ardissino Diego D Bottinger Erwin P EP Erbel Raimund R Franks Paul W PW Girelli Domenico D Hall Alistair S AS Hovingh G Kees GK Kastrati Adnan A Lieb Wolfgang W Meitinger Thomas T Kraus William E WE Shah Svati H SH McPherson Ruth R Orho-Melander Marju M Melander Olle O Metspalu Andres A Palmer Colin N A CN Peters Annette A Rader Daniel J DJ Reilly Muredach P MP Loos Ruth J F RJ Reiner Alex P AP Roden Dan M DM Tardif Jean-Claude JC Thompson John R JR Wareham Nicholas J NJ Watkins Hugh H Willer Cristen J CJ Samani Nilesh J NJ Schunkert Heribert H Deloukas Panos P Kathiresan Sekar S
Journal of the American College of Cardiology 20170201 7
<h4>Background</h4>Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits.<h4>Objectives</h4>This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci.<h4>Methods</h4>In discovery analyses i ...[more]