Ontology highlight
ABSTRACT:
SUBMITTER: Siewert KM
PROVIDER: S-EPMC6291836 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Siewert Katherine M KM Voight Benjamin F BF
Circulation. Genomic and precision medicine 20181201 12
<h4>Background</h4>Plasma lipid levels are heritable and genetically associated with risk of coronary artery disease (CAD). However, genome-wide association studies (GWAS) routinely analyze these traits independent of one another. Joint GWAS for two related phenotypes can lead to a higher powered analysis to detect variants contributing to both traits.<h4>Methods</h4>We performed a bivariate GWAS to discover novel loci associated with both heart disease, using a CAD meta-analysis (122 733 cases ...[more]