Dataset Information

Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential.

ABSTRACT: In the past, numerous methods have been developed to predict MHC class II binders or T-helper epitopes for designing the epitope-based vaccines against pathogens. In contrast, limited attempts have been made to develop methods for predicting T-helper epitopes/peptides that can induce a specific type of cytokine. This paper describes a method, developed for predicting interleukin-10 (IL-10) inducing peptides, a cytokine responsible for suppressing the immune system. All models were trained and tested on experimentally validated 394 IL-10 inducing and 848 non-inducing peptides. It was observed that certain types of residues and motifs are more frequent in IL-10 inducing peptides than in non-inducing peptides. Based on this analysis, we developed composition-based models using various machine-learning techniques. Random Forest-based model achieved the maximum Matthews's Correlation Coefficient (MCC) value of 0.59 with an accuracy of 81.24% developed using dipeptide composition. In order to facilitate the community, we developed a web server "IL-10pred", standalone packages and a mobile app for designing IL-10 inducing peptides (http://crdd.osdd.net/raghava/IL-10pred/).

SUBMITTER: Nagpal G

PROVIDER: S-EPMC5314457 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential.

Nagpal Gandharva G Usmani Salman Sadullah SS Dhanda Sandeep Kumar SK Kaur Harpreet H Singh Sandeep S Sharma Meenu M Raghava Gajendra P S GP

Scientific reports 20170217

In the past, numerous methods have been developed to predict MHC class II binders or T-helper epitopes for designing the epitope-based vaccines against pathogens. In contrast, limited attempts have been made to develop methods for predicting T-helper epitopes/peptides that can induce a specific type of cytokine. This paper describes a method, developed for predicting interleukin-10 (IL-10) inducing peptides, a cytokine responsible for suppressing the immune system. All models were trained and te ...[more]

PMID: 28211521

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Dataset Information

Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential.

Publications

Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential.

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