Ontology highlight
ABSTRACT:
SUBMITTER: Mauri M
PROVIDER: S-EPMC5314787 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Mauri Marta M Kirchner Marieluise M Aharoni Reuven R Ciolli Mattioli Camilla C van den Bruck David D Gutkovitch Nadya N Modepalli Vengamanaidu V Selbach Matthias M Moran Yehu Y Chekulaeva Marina M
Nucleic acids research 20160906 2
Our current knowledge about the mechanisms of miRNA silencing is restricted to few lineages such as vertebrates, arthropods, nematodes and land plants. miRNA-mediated silencing in bilaterian animals is dependent on the proteins of the GW182 family. Here, we dissect the function of GW182 protein in the cnidarian Nematostella, separated by 600 million years from other Metazoa. Using cultured human cells, we show that Nematostella GW182 recruits the CCR4-NOT deadenylation complexes via its tryptoph ...[more]